Chippa come into to the match on a 10-match winless run, after they were beaten 2-0 by Orlando Pirates in midweek, and will hope to break that spell at home tonight.
AmaZulu, on the other hand, have picked up form of late after they claimed a second win from their last three league matches, when they beat Bidvest Wits 3-1 on Tuesday.
However, The Chilli Boys have a head-to-head advantage as they boast an unbeaten record against Usuthu, having won two matches and drawn one of their previous three meetings.
The last time the Durban-side visited Chippa at home, at the Phillipi Stadium in Cape Town, the match ended in a stalemate as both teams scored a goal-a-piece, which was back in the 2012/13 season.
United have since moved to Port Elizabeth, and will hope to better that record at their new home.
The last time these two teams clashed, Mpho Mvelase scored the only goal of the match to hand Chippa the three points in Durban.
Chippa United: Mzimela, Mbenyane, Chipeta, Sambu, Cloete, Moholo, Okwuosa, Twala, Akpabio, Zulu, Uzochukwu.
AmaZulu XI: Murambadoro, Pietersen, Hlanti, Mabizela, Ouro-Akoriko, Johannes, Arwuah, Dlamini G, Nyongo, Ntuli, Mwape.