Usuthu in an official statement announced the departure of 15 first-team players while assistant coach Vasili Manousakis and goalkeeper coach Moeneeb Josephs have also left the club.
Neil Boshoff, Tapelo Xoki, Xola Mlambo, Luvuyo Memela, Tsepo Masilela, Kgotso Moleko, Henrick Ekstein, Abraham Majok, Thabo Qalinge, Siphelele Mthembu, Andre de Jong, Augustine Mulenga and Siyethemba Sithebe are the 15 names headed for the exit door.
"Tapelo Xoki has been acquired by Orlando Pirates while Sithebe has opted to not extend his contract with AmaZulu," club president Sandile Zungu said in a statement.
"As for the others, the club has decided to not renew their contracts in view of our endeavours to rebuild for success in the forthcoming 2022/2023 season.
"We will announce the names of at least eight players who will be joining Usuthu in the coming days.
"The club can also confirm the departure of assistant coach Vasili Manousakis and goalkeeper coach Moeneeb Josephs. We would like to thank all the players and the aforementioned members of the technical team for their service and wish them the best in their future endeavours."