In a week that was set for celebration into a new era of success for Pep Guardiola and his ambitious Citizens squad, the Premier League leaders suffered consecutive defeats, starting with the 3-0 humbling at Anfield in the reverse fixture of the European Cup.
Then, Saturday's 3-2 loss to Manchester United in the Manchester derby compounded further misery on Guardiola's men as they failed to secure the title in front of their home fans after throwing away a 2-0 lead.
Liverpool, on the other hand, come into the fixture brimming with confidence, with the chance of becoming the first team since the 2009/10 season to beat City three times in a single campaign.
The Reds are the highest scoring side in this season's Champions League campaign with 31, with Mohamed Salah grabbing eight of the impressive figure.
Jurgen Klopp's only issues will be the suspension of captain Jordan Henderson, as Mohamed Salah, Andrew Robertson and Alberto Moreno have all returned to first-team training.
Manchester City: Ederson, Walker, Otamendi, Laporte, Fernandinho, De Bruyne, Silva, Sane, Sterling, Bernardo, Jesus.
Liverpool: Karius, Alexander-Arnold, Lovren, Van Dijk, Robertson, Milner, Wijnaldum, Oxlade-Chamberlain, Mane, Salah, Firmino.