Bafana Bafana will be without the services of Goodman Mosele, who was failed to report for duty, and Mosa Lebusa, who has not recovered from injury in time to take part, with SuperSport United duo Jesse Donn and Luke Fleurs called up in their place.
Hugo Broos' side currently top the Group G standings after taking four points from their opening two matches, having recorded a goalless draw in their opening encounter against Zimbabwe before beating Ghana 1-0 at the FNB Stadium.
Elsewhere, the Warriors and the Black Stars will be in action later on Saturday evening in the first of two consecutive clashes between the two nations, who will be hoping to overthrow South Africa at the top of the standings.