Amazulu, Highlands Park and Cape Town City have already come out to confirm facing challenges in paying their players' full salaries since football activities were suspended to the outbreak.
A number of clubs in Europe including Barcelona, Real Madrid and Juventus have confirmed that players have agreed to take pay-cuts while football remains suspended.
However, the Sundowns boss insists his players and all the staff at Chloorkop will continue getting their salaries.
"It's important [to pay the salaries]," Motsepe said during Thursday's press conference in Johannesburg.
"We will continue paying salaries whether there is football or no football. We will continue to pay everybody who works for us their salaries, as if there was no coronavirus.
"It's an obligation. We have to do that."
Motsepe has handed coach Pitso Mosimane a four-year contract extension at Sundowns that could see him become the highest-paid coach in South Africa.