The clash with the Atlas Lions will take place at Agadir New Stadium in Agadir City, southwest of Morocco. It will be an evening match but the kick-off time is still to be confirmed.
The match is one of two between the two nations – with the return leg to be hosted by South Africa in 2014.
The Atlas Lions are the 2015 hosts of the Africa Cup of Nations and have won the competition once, in 1976. They finished second in 2004 in Tunisia and third in 1980 in Nigeria.
Coached by Rachid Taoussi, Morocco are ranked 76 on Fifa world rankings and 16th on the African continent.
South Africa are 68th on world rankings and 12th in Africa.
In their last five matches, the two teams have each won two and drawn the other.