Zamalek on the other hand must win to keep their hopes alive of reaching the semi-finals and will be up against a Bucs side that is improving with each game.
After getting hammered 4-1 by Pirates the last time they played the Egyptians welcome back a couple of players from injury and suspension which could make life tough for Pirates.
The likes of defender Salah Soliman, midfielder Nour El-Sayed, Mahmoud Fathallah and striker Ahmed Gaafar are all available for selection.
Pirates are on top of Group A on seven points with a game in hand followed by Al Ahly also on 7 points but behind Bucs on goal difference.