The first match will be played on Wednesday night, 23 January.
Tickets for all 16 games are selling at R40 for adults and R15 for children below the age of 12. Other ticket-selling outlets include Edgars, Jet, Postnet and CNA.
Former Nedbank Cup champions Bidvest Wits will kick off proceedings when they host Boyne Tigers at Bidvest Stadium, while Polokwane City and Tshakhuma Tsha Madzivhandila FC clash in a Limpopo derby on Wednesday next week. Both fixtures will start at 19h30.
In addition to the 24 clubs from the PSL professional structures, eight clubs from the SAFA amateur ranks await an opportunity to make a name for themselves; five of which will be making their Nedbank Cup debut.
The debutants are: Tshwane University of Technology (Gauteng), Boyne Tigers (Limpopo), NC Professionals (Northern Cape), Umvoti FC (KwaZulu-Natal) and Tjakastad Junior Shepard (Mpumalanga).