The League went on a month-long recess following the opening round of fixtures.
The pick of the matches in round two is a top-of-the-table clash between early pace-setters Sundowns and Cosmos at the Makhulong Stadium today (Monday).
The match kicks off at 4pm.
The Brazilians finished last season second, and began this season with a 4-0 win over Bidvest Wits.
Cosmos are coming off the back of a 3-2 win over Moroka Swallows.
At Rand Stadium, at the same kick-off time, Pirates face defending champions SuperSport.
Matsatsantsa were easy winners of the Reserve League last year, and started this campaign with a 0-0 draw with University of Pretoria.
The Buccaneers beat Kaizer Chiefs 2-1 in their opening fixture.
Amakhosi face Swallows at Delville Sports Grounds today at 3pm, while Tuks do battle with Bidvest Wits in an all-university tie at Tuks Soccer Field A.