Pirates beat Al-Ahly 4-3 in the semi-finals at Suez Stadium in Egypt last night to advance 5-3 on aggregate.
Bucs will contest honours next month with Tunisia's Etoile du Sahel, who edged Zamalek 5-4 across two legs in their last-four tie.
The Sea Robbers - continental champions in 1995 - also reached the final of the Champions League in 2013.
“It is a known fact that Southern African clubs have struggled in continental club championships in the last 10 years or so,” De Villiers said.
“What Orlando Pirates has done and continues to do, is to affirm the belief that club football in the Southern African region is on the ascendancy.
“To reach both CAF Champions League and CAF Confederations Cup final in a space of two years is a massive feat and historical in the South African context.”
He continued: “We need to support them as they attempt to overcome one more hurdle in the final of the CAF Confederations Cup coming up in a few weeks.
“On behalf of the PSL family, we would like to congratulate the club management, technical staff and players for the road travelled so far.
“The PSL wishes them all the best as they prepare for the CAF Confederations Cup two-legged final.”