The Urban Warriors on Friday announced they will not compete in the event, citing an inability to secure the safety of their players for the scheduled trip to Angola to meet Sagrada Esperanca in Dundo this coming weekend.
Ajax face the possibility of being banned from participating in CAF competitions for three years and fined by the continental governing body.
"A withdrawal reported after the engagement and before the establishment of the fixtures leads to the loss of the engaged club with an imposed fine of three thousand (3,000) US dollars," reads a CAF rule.
Ajax coach Roger de Sa confirmed the club's upcoming meeting with SAFA to discuss the issue.
"I was involved in lot of the discussions. A lot of phone calls were made, I speak the language. There were numerous emails, faxes and phone calls to all of the PSL, SAFA, CAF and there is nothing we can do. We didn't get anything back," says De Sa.
"We can't take a risk, it's about the safety and security of the players - that's it. We will hear more tomorrow when we face SAFA and see what the outcome would be."