The White Knights suffered a last-minute defeat to their fierce city rivals in November in the fixture dubbed the Derby of the Century in Cairo.
And after a strong start to the new campaign that sees them level on points with Mosimane's star-studded squad, Pacheco is confident he's capable of securing Africa's elite club competition.
"This season we will reach the Champions League final and we will win the title; this is our main target; this is what I always tell the players; it is why I'm here - because I want to be the champion," he told Al Nahar One.
"We have to win the league this season, it's not right to be behind Ahly by 20 points in the league [as was the case last season]. Zamalek has achieved the same number of points Ahly collected since I arrived.
"Al-Ahly has spent millions on players, specifically in attack and defence, and we will don't offer [as] strong contracts. We are content with loans and despite that, we are equal in the number of points in the league."
1. Mido - 36 games (21 January 2014 - 24 July 2014)
2. Hossam Hassan - 19 games (30 July 2014 - 2 October 2014)
3. Jaime Pacheco - 15 games (10 October 2014 - 1 January 2015)
4. Jesualdo Ferreira - 41 games (8 February 2015 - 21 November 2015)
5. Marcos Paquetá - 5 games (December 2015 - 3 January 2016)
6. Mido 2nd stint - seven games (3 January 2016 - 9 February 2016)
7. Alex McCleish - seven games (27 February 2016 - 2 May 2016)
8. Mohammed Helmy - 15 games (2 May 2016 - 27 July 2016)
8. Moamen Soliman - 10 games (30 July 2016 - 19 November 2016)
10. Mohammed Helmy 2nd stint - 23 games (28 November 2016 - 1 April 2017)
11. Augusto Inácio - 23 games (2 April 2017 - 27 July 2017)
12. Nebojša Jovovic - 18 games (16 August 2017 - 3 January 2018)
13. Ehab Galal - 17 games (3 January 2018 -13 April 2018)
14. Christian Gross - 48 games (3 July 2018 - 1 July 2019)
15. Khaled Galal - 3 games (1 July 2019 - 29 July 2019)
16. Milutin Sredojevic - 12 games (19 August 2019 - 2nd December 2019)
17. Patrice Carteron - 31 games (3 December 2019 - 15 September 2020)
18. Jaime Pacheco - 26 games (28 September 2020-11 March 2021)
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