With RB Leipzig vs Atletico Madrid and Atalanta vs Paris Saint-Germain, the two quarter-final ties already confirmed, the rest of Europe's elite club's learnt their fate at the UEFA headquarters today.
Real and Juventus trail Manchester City and Lyon respectively but could meet in the last eight if they overcome their first-leg deficits.
Bundesliga champions Bayern Munich are likely to face FC Barcelona or Napoli due to their current 3-0 advantage over Chelsea from the first-leg tie that took place in February.
And in the semi-finals, Ronaldo could end up facing his long-standing rival Lionel Messi, should the LaLiga giants and the Bianconeri qualify for the last-four stage of the competition.
The coronavirus enforced suspension of football has seen the tournament format change with all fixtures once-off clashes towards the final which will take place at the Estádio da Luz in Lisbon on 23 August.
QF1: Real Madrid/Manchester City vs Olympique Lyon/Juventus
QF2: RB Leipzig vs Atletico Madrid
QF3: Napoli/Barcelona vs Chelsea/FC Bayern
QF4: Atalanta vs Paris Saint-German
Winner of QF1 vs Winner of QF3
Winner of QF2 vs Winner of QF4