With the pre-match hype surrounding the return of Cristiano Ronaldo to Old Trafford, it promised to be a feisty affair.
Juve made all the earlier attacking, with Ronaldo, Paolo Dybala and Miralem Pjanic seeing loads of the ball.
Dybala silenced the home crowd with a nicely tucked near post conversion after Juan Cuadrado’s initial effort went south on 17 minutes.
The Red Devils were chasing shadows and being behind only worsened their situation, as Juventus looked calm in every move from defence to attack.
Summer signing Joao Cancelo came close to adding a second with a shot from outside the box after playing a one-two with David De Gea.
This dominance continued well after the half and hour mark when Ronaldo’s powerful free-kick was clapped back by David De Gea, with Blaise Matuidi forcing a one-handed save on the follow up.
For the second half, neither side started with changes off the bench with United’s task to launch a come back.
The first half dominance from Juve continued with their free-flowing football, leaving United in sixes and sevens.
A ball from the centre picked out Juan Cuadrado in a wide position to set-up Ronaldo for a stunning shot that forced De Gea to put away for a corner.
With Wojciech Szczesny yet to make a save, the Italians were having a ball in Manchester much to the frustration of a certain Jose Mourinho.
That nearly ended when Paul Pogba found the post with a low left-footed shot from just 10-metres off the box.
It was all Juve towards the end, with Ronaldo nearly adding a second followed by a long-range shot from Leonardo Bonucci.
The victory puts Juventus on top of Group H and with that one foot in the Champions League knockout stages.