Real took the lead in the first-leg that was played out at the Santiago Bernabeu five months ago through Isco but City managed to stage a historic comeback through Gabriel Jesus and a Kevin De Bruyne penalty.
Guardiola, who's yet to win Europe's elite club competition since leaving Real's fierce rivals FC Barcelona in 2011 is now just one game away from inflicting Zidane's first-ever defeat in the knock-out stages.
Zidane lifted a record three consecutive Champions League titles in his first stint at Los Blancos and a win over the Spaniard would mark as a real vindication of the management of the 2019/20 LaLiga winning coach.
He'll be without captain Sergio Ramos (suspended), Mariano Diaz (Covid-19) while star forward Gareth Bale asked to left out of the squad that travelled to Manchester this week.