The LaLiga outfit currently hold an advantage after securing an away goal in the first leg that ended 1-1 before the season was suspended.
While both Napoli and Barcelona have been inconsistent since the restart former Blaugrana midfielder Edmilson feels the Italians can eliminate his former side.
"On Saturday a Champions League match will be played after a long time and the qualification is open for both teams because playing in a situation like this where there are no fans, I believe Napoli can go to Barcelona and take their chances.
"[Gennaro] Gattuso's team must continue to play as they have been doing and not be afraid of Barca, because the Blaugrana won't be scared.
"After the pandemic the league was fraught with difficulty, but they are still Barcelona. They are playing at home and they are always favourites.
"Barca are, however, experiencing a shady moment. A moment where Messi is practically playing alone and loading the whole team on his shoulders.
"They have also changed their coach during the current season."