With Real and Paris Saint-German through to the Champions League last 16, Tau and co will want to put on a performance, to ensure that European football continues for the Belgian giants.
In the build-up to the fixture, Los Blancos boss Zinedine Zidane urged his side to avoid complacency as their trip to the Jan Breydel Stadium could have the potential to unsettle their recent form ahead of the Classico this month.
Despite already qualifying for the last-16 with second-placed secured, Zidane will be looking for his to stretch their unbeaten run to 10 games across all competitions for the first time this season.
For Brugge, the aim is finish in third place ahead of Turkish Super Lig giants Galatasaray, whose result against PSG, they need to match or improve in order to remain in European football this season.
Real Madrid: Areola, Militao, Varane, Odriozola, Mendy, Casemiro, Modric, Isco, Vinicius, Rodrygo, Jovic.