Serie A champions Juventus were stunned 2-0 by Cagliari at the Sardegna Arena on Wednesday evening.
The champions came with a very depleted side with the substitutes bench comprising mostly of youth team players, but Gianluigi Buffon started in goal with talisman Cristiano Ronaldo up front.
Cagliari got the breakthrough when Luca Gagliano positioned firmly in the area to turn home Federico Mattiello's delivery with eight minutes gone.
Ronaldo levelled eight minutes later after directing Federico Bernardeschi's ball beyond Alessio Cragno, but his joy was cut short with the effort disallowed for offside.
An awkward delivery to the back-post landed kindly to Gonzalo Higuain who went for a spectacular volley only to flash off target in the last eight minutes of the half.
Cagliari stunned the recently crowned champions again in stoppage time when Giovanne Simeone combined with Gagliano from range to sent a thumbing strike past Buffon.
The home side opted for a double change after the break, as Alberto Paloschi and Charalampos Lykogiannis entered in favour of Gagliano and Marko Rog respectively.
Juventus began upping the tempo ten minutes from the restart, forcing Cragno into a double save off threatening attempts from Alex Sandro and Simone Muratore.
Simeone almost completed his brace inside the last 20 minutes after charging onto a loose ball before going wide after Leonardo Bonucci blocked an attempt.
Very little materialised from the league champions despite Ronaldo getting a shot away from an awkward angle which Cragno parried in the final minutes, as Cagliari ran out winners on the day.
Lazio 2-0 Brescia
Lazio remain in contention for second place in the Serie A with a 2-0 win over already-relegated Brescia on Wednesday evening.
Lazio took the lead inside the opening 17 minutes when Correa rewarded Simone Inzaghi for the faith shown in him by drilling home Ciro Immobile's supply.
It was all Lazio who had Lorenzo Andrenacci to work after Jony delivered a telling ball which Immobile picked up to bring their opposite number to a smart block whilst the half concluded.
With no changes from either side at the break, Lazio were in search of a second with Immobile managing to go on the charge before taking aim at Andrenacci who stood strong.
Brescia, who struggled to get out of first gear earlier on, continued battling though with little success with the highly-rated Sandro Tonali plugging away continuously.
The Eagles from Rome went for a double change just after the 55th minute, as Lazzari and Jony made way for Jordan Lukaku and Adam Marusic respectively.
Lazio didn't stop threatening after Sergej Milinkovic-Savic went in on goal with a snap shot eleven minutes later, but it proved no trouble to Andrenacci.
Immobile ensured three points for Lazio after getting ahead of the defence to turn home his 35th of the season in the final seven minutes.
The visitors looked for a consolation, but failed to find any as the Eagles picked up a third straight win in the league.