Aguero bagged his 150th Premier League goal in his 217th appearance for Manchester City against Southampton - only Alan Shearer (212 games) has scored 150 in fewer games in Premier League history.
The Citizens' star man scored their second of the afternoon, tapping home a simple finish after being set up by excellent work from Raheem Sterling.
Aguero became the ninth player to hit 150 with the strike and – at 30 years of age, will seemingly surpass some of the league's greatest ever goalscorers.
10. Les Ferdinand (149 goals, 351 games)
9: Michael Owen (150 goals, 326 games)
8: Sergio Aguero (150 goals, 218 games)
7: Jermain Defoe (162 goals, 492 games)
6: Robbie Fowler (163, goals 379 games)
5: Thierry Henry (175 goals, 258 games)
4: Frank Lampard (177 goals, 609 games)
3: Andy Cole (187 goals, 414 games)
2: Wayne Rooney (208 goals, 494 games)
1: Alan Shearer (260 goals, 441 games)