Manchester United will make the trip to League Two outfit Yeovil Town, while Manchester City will face the winner of the replay between Cardiff City and Mansfield Town.
Liverpool, who saw off rivals Everton in the last round, will host West Bromwich Albion at Anfield.
The only other all Premier League tie will see Southampton face Watford at St. Mary's.
Liverpool v West Bromwich Albion
Peterborough United v Fleetwood Town/Leicester City
Huddersfield Town v Birmingham City
Notts County v Wolves/Swansea City
Yeovil Town v Manchester United
Carlisle United/Sheffield v Stevenage/Reading
Cardiff City/Mansfield Town v Manchester City
MK Dons v Coventry City
Millwall v Rochdale
Southampton v Watford
Middlesbrough v Brighton/Crystal Palace
Bournemouth/Wigan Athletic v Shrewsbury Town v West Ham United
Hull City v Nottingham Forrest
Newport County v Tottenham Hotspur
Norwich City/Chelsea v Newcastle United
Sheffield United v Preston North End