Affonso last played for Sundowns in February 2020 in a CAF match against Wydad Casablanca but could finish the current season without touching the ball as he continues to suffer with injuries since his arrival at Chloorkop.
The Uruguayan striker underwent surgery during Level 5 lockdown in South Africa and returned to training at the start of the 2020/21 season.
However, Sundowns co-coach Manqoba Mngqithi has confirmed that Affonso has been hit by injuries again and may need a few more months before he can appear in the blue and yellow colours again.
"Affonso is still out, we will be not really sure when he is coming back because he always breaks down when we are hoping that he is coming back," he admitted after the league win over Orlando Pirates on Saturday.
"We are beginning to live with the fact that maybe he must recover fully and be ready to help us when he is ready. We believe that maybe in the next two to three months, if not four months [he will be back], but it's a tough one for us."
Sundowns are set to welcome Jwaneng Galaxy to Tshwane in the CAF Champions League on Tuesday having won 2-0 in Botswana before Christmas Day last year.
Kick-off has been adjusted to 16h00 to accommodate South Africa's 20h00 sporting curfew.
Aubrey Modiba - SuperSport United boss Stan Matthews has confirmed that the versatile left-sided player's move to Sundowns is done.
Luvuyo Phewa - This signing went under the radar, but Real Kings confirmed a deal with Sundowns for the former SA under-20 star. He has since been loaned to Chippa United.
Lesedi Kapinga - Black Leopards' most exciting player this year signed a pre-contract with Sundowns in January and was allowed to leave before the resumption of the 2019/20 season.
George Maluleka - 'Mido' signed a pre-contract with Mamelodi Sundowns in January and was then sidelined him from the team and allowed to leave for Chloorkop during lockdown.
Gift Motupa - Sundowns finally landed their long-time target during lockdown after missing out in past transfer windows.
Mothobi Mvala - The former SA under-23 star's move is a surprise considering the sheer volume of midfielders at Chloorkop. A quality signing Sundowns just could not pass up.
Peter Shalulile - The 16-goal Namibian striker has expressed his excitement about the move after Highlands Park was sold to Tim Sukazi.
Kermit Erasmus - Unveiled by Mamelodi Sundowns on a three-year deal.
Khuliso Mudau - The right-back has signed a five-year deal with Sundowns.
Haashim Domingo - The exciting Ajax Cape Town youth product was the second ex-Wits star to confirm to snl24.com/kickoff that he had joined Sundowns.
Grant Margeman - SA under-23 international midfielder Margeman was signed in 2019 and then sent to Ajax Cape Town for the 2019/20 season.
Jody February - February was signed from Ajax Cape Town in 2019 and then loaned to Cape Umoya United for the 2019/20 season.
Ricardo Goss - The goalkeeper was the first of three former Bidvest Wits players to indicate to this website that Sundowns had signed him.
Brian Onyango - The 26-year-old Kenyan defender was snapped up on a three-year deal after initially being unveiled by TTM.
Rushine De Reuck - The 25-year-old has been signed from Maritzburg United on a five-year deal.
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