With the Puskas Arena in Budapest sold out with an estimated capacity of 55 000 supporters for the match, members of the crowd were reportedly heard making monkey noises towards the Paris Saint-Germain star, according to De Telegraaf.
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It is claimed that Karim Benzema, who has Algerian roots, was also insulted.
This will be the second time Hungarian fans have been heard directing foul chants and gestures at opposition at the same stadium during this tournament, with Cristiano Ronaldo having allegedly being labelled a "homosexual" during Portugal's match against the same opponents last Tuesday.
UEFA have confirmed they are launching an investigation into the "potential discriminatory incidents" during Hungary's two games to date.
"In accordance with Article 31(4) of the UEFA Disciplinary Regulations, an UEFA Ethics and Disciplinary Inspector has been appointed to conduct a disciplinary investigation regarding potential discriminatory incidents which occurred in the Puskas Arena, Budapest," a statement from European football's governing body read.
Hungary have been punished by authorities in the past for racism from their supporters, with the country's football federation receiving a €70 000 fine in 2015 for incidents of during a draw with Romania.
Anti-discrimination group FARE has filed an official report to UEFA after a homophobic banner was spotted at the Puskas Arena with the abbreviation "Anti-LMBTQ", which is the Hungarian abbreviation for Anti-Lesbian, Gay, Bisexual, Transgender and Queer.
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