Atleti got their revenge on Dortmund for the first-leg defeat after grabbing a 2-0 at the Wanda Metropolitano.
The result opens up the group with both sides now level on nine points after goals from Saul Niguez and Antoine Griezmann later on in the second half.
Tottenham kept their Champions League hopes on track with a come from behind 2-1 win over PSV at the Wembley Stadium.
After going down to a Luuk de Jong opener after two minutes, a double from Harry Kane ensured their campaign comes alive after losing and drawing their opening two matches.
As for PSV, their campaign in Europe is pretty much over having lost three of their four matches to date.
Porto trounced Lokomotiv 4-1 to strengthen their quest to top the group and qualify for the group stages at the Estadio DragoOtav.
The goals came from Hector Herrera, McDonaldo Marega, Jesus Corona and Otavio Monteiro was enough to see them through.
The consolation strike for the visitors saw Jeferson Farfan finding the net early on in the second half in front of a packed arena.
Schalke took a giant step towards qualification with a 2-0 victory over Turkish champions Galatasaray at the Veltis Arena.
Guido Burgstaller made the most of a defensive error to give them a halftime lead before Mark Uth rounded off the win late in the second half.