Spurs made a positive opening as Lucas Moura brought down a looping ball to flash a half-volley wide in the 10 opening minutes.
Upon retrieving possession high up the field, Dortmund forced Hugo Lloris into an uneasy save following a shot from Christian Pulisic on 15 minutes.
Whilst the match evened out, Spurs almost surrendered before halftime but a superb one-handed save from Lloris kept out Dan-Axel Zagadou’s near post header.
Shortly after the break, A well executed cross from Jan Vertonghen from the left landed found Son Heung-Min, who side-footed in the opener from six-yards out.
The Germans failed to pick up their game towards for most of the half, with Spurs dominating every areas of the field.
As such, Spurs doubled their lead on 83 minutes when Vertonghen rounded off an impressive performance as he showed his striker’s instinct with a near-post finish on 83 minutes.
Fernando Llorente added to the visitors woes when he raced ahead a Dortmund defender to glance home the third from a Eriksen cross as Dortmund ran out 3-0 winners on the night.