On Friday night, German outlet Der Spiegel reported dropped a huge leak claiming Ramos tested positive for Glucocorticoid Dexamethasone after the 2017 Champions League final in Cardiff, Wales.
In the heated fixture, where Los Blancos picked up a second consecutive Champions League title with a 4-1 win over Juventus, the report also adds that UEFA covered it up with no action taken against the Spanish superstar.
"The deputy head of the Seibersdorf laboratory sent a report to the headquarters of the Union of European Football Associations, better known as UEFA, on the shores of Lake Geneva. The Austrians had analyzed the sample and found that it contained traces of dexamethasone, a cortisone preparation that has an anti-inflammatory effect in addition to relieving pain," read the statement from Football Leaks.
Real have since responded and so has Ramos following the clubs humiliating 3-0 defeat to Eibar, in which the La Roja skipper started in.
"That is a very difficult issue, complicated. I must come out and defend myself, with my legal team, against these allegations," Ramos said. "I have been through 250 or 300 doping tests over my career, and never failed one, there has never been any irregularity.
"We know the type of publication this is. They threatened us with the news a month and a half ago. When you know the truth, you are not afraid of lies. It is an attempt to stain my image and my professional reputation."
In a statement released shortly after the leak, the LaLiga giants backed their star man; "With regards to the reports published by Der Spiegel in relation to our captain, Sergio Ramos, the club wishes to express the following: Sergio Ramos has never breached anti-doping regulations.
"UEFA requested specific information and immediately closed the case referred to, as is customary in such instances, following tests carried out by experts from the World Anti-Doping Association (WADA) and UEFA itself."
And Ramos teammate at international level Jordi Alba believes the 32-year-old is innocent amidst the serious allegations.
"Ramos is a good [football] player. There are few professionals like him. He lives for [Real] Madrid and for the [Spain] national team. I think he’s right and what has been said is not true," SPORT quoted Alba as saying.
"It doesn't concern me, but I don't like talking nonsense."
Football Leaks, via the German publication, have also made claims on Manchester City and PSG reportedly breaking UEFA's rules on Financial Fair Play as well as several transfer scandals.