Messi has been tipped to take centre-stage in the first-leg at Stamford Bridge but if history counts for anything, the five-time Ballon d'Or winner may be up against it as he looks to end an incredible unwanted record.
In his eight previous encounters against the Blues, the 30-year-old has failed to score against the Premier League side and remarkably he also hasn't scored in the last eight games against goalkeeper Thibaut Courtois, who had a spell in LaLiga on-loan with Atletico Madrid.
However, the Argentina international will be confident of ending the Blues curse due to his impressive recent form as he looks to finally reach a century of goals in the UEFA Champions League.
The Blaugrana star is currently on 97 goals in 121 appearances in Europe's elite club competition.