The clash takes place at Heroes National Stadium in Lusaka, Zambia. Kick-off is at 14h00. It will broadcast live on SuperSport 9.
Senong says all the players must get game-time as the team is now preparing for the 2017 FIFA U-20 World Cup, which will take place in South Korea in May.
Goalkeeper Sanele Tshabalala will make his debut in goals.
The rearguard sees captain Tercious Malepe partner up with another debutant Siyabonga Ngezana at centre-back, while Katlego Mohamme returns to the left-back position. Aghmat Ceres will get his first run at right-back.
Grant Margeman and Wiseman Meyiwa will continue controlling the tempo of the game in the heart of midfield.
Liam Jordan, Sipho Mbule and Kobamelo Kodisang will be the attacking trio, while Itumeleng Shopane is the lone striker up front.
“It is imperative that all the players get a run in this tournament, hence the changes. We will keep the same style of play that has made us get this far. Guinea is a great opposition for us as we start preparing for the World Cup and we believe that we can take the bronze medal home,” said Senong.
“We want to see all the other players, those who haven’t played, how they behave in a match situation. After this tournament we have to sit down with the technical team and start working on the final squad, so giving these players a chance will also help us to make the right decisions.”
Luther Singh, Thendo Mukumela, Sibongakonke Mbatha and Sandile Mthethwa, who have been ever-present since the start of the tournament, have been rested.
This will be the first ever meeting between South Africa and Guinea.
The final between hosts Zambia and Senegal will kick off at 17h30 at the same venue.