Angelo Kerspuy, Tebogo Potsane, Sinethemba Jantjies and Makhehleni Makhaula are all battling with knocks, according to the club's website.
Midfielder Kerspuy, who played 17 times in the league last season, has strained his right ankle and faces a further two weeks on the sidelines.
Potsane has a broken finger, while winger Jantjies and Makhaula both have knee problems. It is unclear when the trio will be able to return to action.