With Chiefs scoring two away goals in a 2-2 draw in the first leg, MTN8 champions United will have to take the initiative at FNB Stadium.
Mokoena said they found themselves in this situation before in the Confederation Cup and came out tops.
"We played in CAF and we experienced something like this playing draws at home and away we win," Mokoena said.
"If you look at our team almost all the players have the experience from CAF. Bongani Khumalo, who joined us now, got that experience from international level. If you check our team again we have experience and I don't think we will struggle in that game."
Mokoena is giving little thought to Amakhosi's struggles in the league.
"We are expecting a tough match because if you look in the MTN8 they are on a good run but in the league they are not doing well.
"But we must not think about them, we must think about ourselves as a team."