The Buccaneers face Tunisian side Etoile du Sahel in the first leg at Orlando Stadium this Saturday, with the return leg a week later at Stade Olympique de Sousse.
Mbalula acknowledges Pirates face a very tough task, but feels they can pull it through and clinch another continental title.
“Pirates have a chance,” he says. “It will be good for South Africa if Orlando Pirates can win the CAF Confederations Cup for us.
“This what we want; I know the boys can do it. They have played very, well and have beaten the best teams in their own backyard. There is no turning back now.”