After recently celebrating their 42nd league title, Al Ahly quickly had to shift focus to a cup quarter-final.
The Egyptian champions were without the services of star winger Mahmoud Kahraba, who had tested positive for the coronavirus this week.
Walid Soliman opened the scoring for the Egyptian giants with a quarter of an hour gone before the Fertilizers were reduced to ten men in the 26th minute when Ibrahim Ragab was sent off.
And Mosimane's men would immediately capitalise on their numerical advantage, with Soliman grabbing his second in the 25th minute and what would be the eventual winner.
If Al Ahly are to go all the way, it will already be the former Mamelodi Sundowns mentor's second piece of silverware since joining the club at the end of last season after guiding the Brazilians to a domestic treble.
Al Ahly will now turn their attention to next Friday's CAF Champions League final against fierce rivals Zamalek.
1. Manuel Jose (1 January 2004 - June 2009) - Egyptian Premier League x5, Egypt Cup x2, Egyptian Super Cup x4, CAF Champions League x3, CAF Super Cup x3
2. Hossam El Badry (22 June 2009 - 22 November 2010) - Egyptian Premier League, Egyptian Super Cup
3. Manuel Jose (31 December 2010 - 19 May 2012) - Egyptian Premier League
4. Hossam El Badry (21 May 2012 - 6 May 2013) - 1 CAF Champions League
5. Mohamed Youssef (29 April 2013 - 30 April 2014) - CAF Champions League, CAF Super Cup
6. Fathi Mabrouk (1 May 2014 - 7 July 2014) - Egyptian Premier League
7. Juan Carlos Garrido (8 July 2014 - 3 May 2015) - CAF Confederation Cup, Egyptian Super Cup
8. Fathi Mabrouk (4 May 2015- 5 October 2015)
9. Jose Peseiro (16 October 2015 - 18 January 2016)
10. Martin Jol (28 February 2016 - 22 August 2016) - Egyptian Premier League
11. Hossam El Badry (24 August 2016 - 15 May 2018) - Egyptian Premier League, Egyptian Super Cup, Egypt Cup
12. Patrice Carteron (12 June 2018 - 22 November 2018)
13. Martin Lasarte (30 December 2018 - 17 August 2019) - Egyptian Premier League
14. Rene Weiler (31 August 2019 - 30 September 2020) - Egyptian Premier League, Egyptian Super Cup
15. Pitso Mosimane (30 September - present) - CAF Champions League, CAF Super Cup, Egyptian Cup
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