The Serie A Champions face off against the Premier League opposition in the last-16 round of the UEFA Champions League, with the first-leg fixture taking place on Tuesday evening at the Juventus Stadium.
Chiellini, 33, has six Serie A titles and 96 senior Italy caps under his name but concedes the Bianconeri will need to produce an incredible collective performance to maintain their clean sheet record of 2018 against the free-scoring Spurs.
"[Kane]'s an extraordinary striker and his stats over the past two years prove it, and he's a player who's grown a lot over recent years," Chiellini told reporters about the Premier Leagues top-scorer, as quoted via KweseESPN.
"He's got the characteristics which make him one of the best in the world and Tottenham are lucky to have him because he's a rare commodity. Thinking of stopping Kane one-on-one, just me - is not going to happen.
"My interest is that Juventus stop Tottenham and this is the most important thing. We'll try to beat them as a team because you can win some battles individually, but only as a team can you stop them."