Real hold a 3-1 aggregate lead after the first-leg at the Santiago Bernabéu and start as overwhelming favourites, despite the home side boasting an impressive domestic record with one of the most expensively assembled squads in Europe.
The Ligue 1 leaders will be without their world-record signing Neymar after the Brazil international underwent surgery in his native country this past weekend after suffering a fractured metatarsal in his right foot.
Kylian Mbappe is also doubtful but is expected to play some part in the encounter, with Unai Emery's job likely to hinge on gaining a result against the LaLiga giants.
Zinedine Zidane is under similar pressure at Los Blancos after a below-par league campaign, as they languish 22 points below league leaders FC Barcelona.
A third successive Champions League title is likely to be the only way the Frenchman will save his job.
However, Zidane can call upon five-time Ballon d'Or winner Cristiano Ronaldo into the starting XI, with the Portugal international having scored 14 goals in his last 10 games across all competitions.
Paris Saint-Germain: Areola; Alves, Thiago Silva, Marquinhos, Yuri; Motta, Rabiot, Verratti; Mbappé, Cavani, Di María.
Real Madrid: Navas; Carvajal, Ramos, Varane, Marcelo; Vazquez, Casemiro, Kovacic, Asensio; Ronaldo, Benzema.