With the title in sight, PSG went with one change from last week's 6-1 hammering of Clermont Foot with Marquinhos restored in defence ahead of Sergio Ramos.
Following a rather even opening seconds, the Parisans were in front on 12 minutes when a delightful cross from Marco Verratti saw Neymar Junior charge and volleyed superbly beyond Pau Lopez.
The breakthrough allowed the Parisans to settle and see a lot of the ball although they could've had a second midway in the first half, but Lionel Messi's promising free-kick missed target.
Marseille weren't overawed by this being the 85th La Classique and as such levelled just after the half-hour mark after Duje Caleta-Car made the most of a goal-mouth scramble in the area.
No sense of nervousness from PSG appeared as they regained the lead before halftime when Kylian Mbappe executed from the spot after a pitch-side review saw Valentin Rongier handle Neymar's shot.
Marseille reshuffled their set-up following the break and introduced Amine Harrit in the place of Cengiz Under who is on-loan from Serie A outfit AS Roma.
It was a lively opening period in the second half for the two giants, with loads of ball retentions which catapulted to a few half-chances that neither their front contingent pounced upon.
PSG were reduced to limited openings late on which led them to introduce Georginio Wijnaldum for Idrissa Gueye in the hope of consolidating their slender lead.
Marseille seemed to have levelled in the final five minutes through a volley from William Saliba following a free-kick by Dimitri Payet, but he was deemed offside.
The Parisans remained calm with time running out and confirmed their victory in the famous Le Classique.