Benzema has not featured for the two-time World Cup winners since 2015 after his alleged role in blackmailing countryman Mathiey Valbuena over a sex tape.
Benzema has been standout player for Los Blancos over last five years and Pires feels that form warrants a call-up, despite his the issues with Valbuena.
"It's a tricky issue, one that has created and continues to create a lot of debate in France," he told AS.
"I'm not really interested in whatever happened between him and [Mathieu] Valbuena, but given all that he has achieved and is achieving at Real Madrid, of course he deserves a France call-up.
"He's one of the best strikers in Europe. But [France boss Didier] Deschamps has the final say."
Benzema notched up 81 appearance for the French national side, while scoring 27 goals in the process before his exile.