Germany, who became the first nation to qualify for the World Cup last month, were in a rampant mood after registering a 9-0 win over Liechtenstein in Wolfsburg.
This victory maintained their perfect record in Group J and with Jens Hofer's early dismissal, Ilkay Gundogan's netted the first from the spot as an own-goal from Daniel Kaufmann followed.
Doubles from Leroy Sane and Thomas Muller followed goals from Marco Reus and Ridle Baku as another own-goal this time from Maximilian Goppel ended the rout.
Spain climbed to the top of Group G at the expense of Sweden following a 1-0 win over Greece away in Athens.
A first-half strike from the penalty-spot by Pablo Sarabia on the back of a foul in the area were all the visiting team needed to snatch victory ahead of their final group stage clash with Sweden.
Portugal will have to wait for their final clash in Group A to determine whether they automatically qualify for the 2022 FIFA World Cup after playing to a goalless draw with the Republic of Ireland on Thursday.
Manchester United's Cristiano Ronaldo skippered the Portuguese, whilst veteran defender Pepe saw red late on as Saturday's showdown with Serbia lie and wait.
Sweden's chances to extend their lead at the top of Group B in the World Cup qualifiers were dealt a blow following a 2-0 loss against Georgia in Batumi.
The Swedes had a chance to go five points clear ahead of second-place Spain, but a double late in the second half from Khvicha Kvaratskhelia ruined their hopes.
All is not lost for Sweden though as a mouth-watering top-of-the-table clash against La Roja on Sunday in Seville awaits.
Romania failed to close-in on second spot in Group J with a frustrating goalless draw against Iceland at home ahead of their group stage finale against Liechtenstein on Sunday.
The draw has the host stuck in third spot in the group, a point behind second-place North Macedonia as the race for second spot enters the final match day.