In what will be Wenger's last visit to Old Trafford, a ground where he experienced career highs and lows (winning the 1998 title and the 8-2 defeat in 2011) his side's form guide doesn't make for encouraging reading.
The Londoners are the only club in the top four English divisions to have lost all of their away league fixtures in 2018.
In Wenger personal duel with Mourinho, the Red Devils boss remained unbeaten in the first 13 but has lost two of the last five.
However, with four wins and three draws, he's never lost at home against 68-year-old the in seven meetings.
In the build-up to this historic Premier League rivalry, Manchester United head coach, Mourinho's who's public conflict with Wenger dates back to his first stint with Chelsea, conceded his admiration for the veteran tactician.
"We had big matches, big fights, so thank you so much for that," he told BBC Football. "Regret? Little negative episodes, yes I do. There were little things where it would be obviously better without them, you know, some gestures, some words, it would obviously be better without it."
With personal victories and pride more at stake than league points as a priority, the visitors may look to rest some of their key players in hindsight of their UEFA Europa League semi-final with Atletico Madrid.
Wenger will be aiming for the European title as his final major silverware before departing, in order for the Gunners to return to the UEFA Champions League next season.