The striker exploded on to the Premier League scene when he netted a stunning winner for Everton against Arsenal aged 16 and he moved to United two years later.
Rooney arrived at Old Trafford on a six-year deal for a transfer fee of 25.6 million pounds in August, 2004.
Here is a look at his top ten greatest moments at the club he spent 13-years at:
Rooney scored a hat-trick on his United debut in a 6-2 victory over Fenebache in the UEFA Champions League.
Less than thirty days later, the striker played a pivotal role in ending Arsenal’s incredible 49-game unbeaten run as Arsene Wenger took his championship side to Old Trafford.
The player celebrated his 19th birthday and with that won a penalty – which Ruud van Nistelrooy buried in the back of the net - and scored the winning goal.
A goal that will forever stick into the memory of United fans was against rivals Newcastle United, as Rooney volleyed ball into the top corner that left Shay Given no chance.
Rooney comes to the rescue for Red Devils once again as his double against Portsmouth ensured Sir Alex Ferguson’s charges advance to the next stage of the FA Cup.
After slotting in his first goal from close range, through a Ryan Giggs assist, Rooney did the unexpected when he lobbed the ball over David James 20 metres from goal.
Lifting his first Premier League title at the end of the 2006/7 season, Rooney went on a four-match goal drought.
It was against Bolton Wanderers, that the striker returned to his old self and scored his 50th and 51st goal.
Courtesy of a Cristiano Ronaldo assist, Rooney chipped the ball with ease over Jussi Jaaskelainen and the winning strike was a sublime finish as he half-volleyed the ball past the ‘keeper.
Finished the 2009/10 season with career-best tally of 34 goals and was rewarded with PFA player of the year award.
Not much to say about Rooney’s winning bicycle goal against arch-rivals Manchester City but it was certainly his best goal in United‘s famous red.
A deflected cross from Nani landed in the path of striker and the rest as they say is history.
The Red Devils thrashed Arsenal 8-2 on the day and ‘Wazza’ leaded the scoring tally with a hat-trick.
His first goal was a superb free-kick that Wojciech Szczesny could only punch into the top of the net while his second strike left the ‘keeper stranded in yet another dead-ball situation.
Rooney capped off his hat-trick with a penalty.
Rooney becomes only the third player to achieve 100 Premier League assists during United's 3-1 win over Swansea City.
The 31-year-old surpassed Bobby Charlton to become the club's leading scorer after netting his 250th goal to secure a 1-1 draw at Stoke City in January, 2017.