New Arsenal boss Unai Emery will face the daunting task of facing Pep Guardiola's Citizens at the Emirates for the English top-flight debut.
Manchester United face off against an unpredictable Leicester City at Old Trafford, while Liverpool host West Ham.
Arsenal v Manchester City
Bournemouth v Cardiff City
Fulham v Crystal Palace
Huddersfield Town v Chelsea
Liverpool v West Ham United
Manchester United v Leicester City
Newcastle United v Tottenham Hotspur
Southampton v Burnley
Watford v Brighton
Wolverhampton Wanderers v Everton