An early goal inside two minutes from Grant Peters saw Orlando Pirates defeat Mamelodi Sundowns 1-0.
The Buccaneers were captained by Ntsikelelo Nyauza in what was a first game in charge for coach Zipho Dlangalala.
Goals from newly-signed defender Keorapetse Molete, Colin Ryan, Thomas Chideu and Masilake Phohlongo saw the Ajax cruise to victory.
Maritzburg United and Highlands Park played to a 1-1 draw. The KwasZulu-Natal side took the lead after Luyanda Ntshangase, but were pegged back by a second-half equaliser from Muzi Thabotha.
In Port Elizabeth, Chippa United defeated Platinum Stars 1-0 thanks to a goal by Bulumko Ceki, while Free State Stars beat Polokwane City 2-1.