Leopards were unchanged for the third game running, while Grant Kekana, Jamie Webber, Sipho Mbule and Kudakwahse Mahachi were United's four changes from the win over Polokwane City.
The early inroads came from United three minutes in, as Bradley Grobler headed wide of the far corner following a précised delivery from the right by Mahachi.
Grobler was set through again following a ball through the middle after ten minutes, but King Ndlovu was on guard to narrow the angle before turning Mahachi's free-kick over the top a little later.
Leopards grew in confidence after the 20th minute and had SuperSport shot-stopper Ronwen Williams punching Mwape Musonda's long-range strike back into play before Tumelo Khutlang hoofed the follow-up.
Matsantsanta did have the ball in the back of the net a minute before the waterbreak after Grobler nodded into the bottom corner from a free-kick, but it was ruled out following an indiscretion.
Musonda went close to claiming the opener seconds before the break following a corner-kick from the right, but headed wide while Ndlovu kept out Mahachi at the other end.
Matsatsantsa made the first substitution two minutes from halftime, as Clayton Daniels made way for veteran fullback Onismor Bhasera.
Kaitano Tembo's side were given a lifeline when the man in the middle pointed to the penalty spot on 72 minutes following a foul in the area, but Grobler was unable to profit as Ndlovu pulled off a save.
Ndlovu was finally beaten when Ghampani Lungu slotted home a loose ball from close-range on 86 minutes, while the goalkeeper's evening ended following a collision with Jonas Mendes filling in.
SuperSport successfully ran down the clock to regain third spot and go six points behind table-topping Kaizer Chiefs.
Leopards: K. Ndlovu, Mudau, Zulu, Masia, Gyimah, Abubakar, Makgetlwa, Hlongwane, Thutlwa, Musonda, Khutlang
Subs: Mendes, Ndawonde, Ndou, Mokoena, T. Ndlovu, Modiba, Adrianarimanana, Ng'ambi
SuperSport: Williams, Daniels, Kekana, Ditlhokwe, Fleuers, Mokoena, Webber, Mbule, Mahachi, Lungu, Grobler
Subs: Pule, Khumalo, Nhlapo, Bhasera, Donn, Moralo, Modiba, Appollis, Gabuza.