The Clever Boys will host the Brazilians in the MTN8 final at Mbombela Stadium, in a PSL first which pits last season's league champions against the runners-up.
'Tyson' has faith his side can get the better of Sundowns, who also reached the CAF Champions League final in September.
“We know the team well, we have studied their games, and many of us know their players personally," Hlatshwayo told his club's website.
“They are a good team but we have not made it to the final by going for anything but the win,” added the Bafana Bafana defender.
Wits saw off Orlando Pirates and Cape Town City en-route to the final, while Downs disposed of Tshwane rivals SuperSport United and Chippa United.