SuperSport had a depleted side with only four players on the bench, but managed to get a draw in a game that never reached any great heights.
Matsatsantsa barely tested the Horoya goalkeeper, and bar the final 10 minutes looked comfortable in defence themselves.
The point leaves them on seven points from five matches and in second place in their pool, but TP Mazembe are just a point back and have a game in hand.
SuperSport host CF Mounana from Gabon in their final game next weekend.
SuperSport: Williams, Kekana, Daniels, Gould, Modiba (Bhasera 90'), Furman, Letsholonyane, Morton, Phala, Mnyamane, Nkhatha (Brockie 66').