The match-ups were decided by CAF via a draw in Cairo on Tuesday morning.
The draw pitted 16 teams that advanced in the second-tier event against sides eliminated from the Champions League.
Wits bowed out of the Champions League with a 1-0 aggregate loss to Al-Ahly on the weekend, while SuperSport and Stars saw off Al-Ahly Shendy and Vipers SC respectively in the Confed Cup.
The two-legged contests are set for the weekends of April 7 and 14.
Kings of Africa Mamelodi Sundowns are still awaiting a date for their Champions League group stages draw.
Sundowns started their title defence with a 3-2 aggregate win over Uganda's Kampala Capital City Authority.
Young Africans vs MC Alger
TP Mazembe vs JS Kabylie
AC Leopards vs Mbabane Swallows
FUS vs MAS
Rangers vs Zesco United
CF Mounana vs ASEC Mimosas
Rail Club K vs CS Sfaxien
Bidvest Wits vs Smouha
CNAPS vs CRD Libolo
Kampala CCA vs El Masry
Gambia Ports vs Al Hilal Obeid
ASPL 2000 vs Club Africain
Rivers United vs Rayon Sports
BYC vs SuperSport United
AS Tanda vs Platinum Stars
Horoya AC vs IR Tanger