Mamelodi Sundowns will become the first South African club to reach yet another CAF club competition milestone when they continue their quest for a second star.
Sundowns' growing status on the continent has been demonstrated by the fact that they are now due to become the first South African club to reach 150 CAF club competition matches when the quarter-finals kick off next month.
Sundowns reached a century in May 2017 when they visited AS Vita with their first ever match on the continent coming against Arsenal of Lesotho in the 1994 African Cup of Champions Clubs first round.
South African clubs only started playing continent football in 1993 following the country's readmission to international football the previous year.
Sundowns have now gone to play in all the CAF club competitions – the Champions League (formerly African Champions Cup), CAF Confederation Cup, CAF Super Cup and the disbanded African Cup Winners' Cup.
The Brazilians have played Champions League football for the past seven years in a row and were champions in 2016 going on to win the Super Cup the following year.
They will meet any of Simba SC, Esperance, or Kaizer Chiefs in the two legged last eight ties which will be games number 150 and 151 on the continent.
Of the domestic big three, Orlando Pirates have played the second highest number of CAF club competition games at 114.
The Buccaneers were winners of the Champions League in 1995 and have been losing finalists in both the two CAF club competitions over the last eight years.
For all their success in domestic football, Kaizer Chiefs have not played much football on the continent through the years.
They have a 'bad record' of being disqualified, then getting banned and sending weakened teams minus their head coach for some away assignments.
AmaKhosi have played just 50 games on the continent but were winners of the African Cup Winners Cup in 2001.
They have reached the group stages and then quarterfinals of the Champions League for the first time this year and will be drawn against any of Sundowns, Esperance or Simba.
The Champions League is now the only trophy that Chiefs still a chance of winning, which will end the six-year trophy drought that they have been enduring.
Reaching the Champions League guarantees R9.5-million this year.