The Red Devils have faced an incredible fixture pile-up during the pandemic with the 2020/21 Egyptian Premier League campaign not even reaching its halfway point yet.
With the season starting in December due to several postponements leading to the late finish of the 2019/20 campaign, the travelling requirements for the CAF Champions League and FIFA Club World Cup has taken its toll on the first team.
Tunisia international left-back Ali Maaloul has suffered two injuries in quick succession while Hamdy Fathi and Mohamed Hany have suffered long-term setbacks.
Youssef, who won 16 major titles with the club and the 2013 CAF Champions League as a coach, feels it's time for Mosimane to tweak his training methods to allow his players to recover better.
"There are too many injuries. Mosimane must check the physical load he puts on the players because he's the coach and he's the one responsible," the 95-time capped Egypt international told OnTime Sports.
"If the same injury is repeated to more than one player, then the coach should immediately suspect something. Five Al Ahly players have suffered hamstring injuries, which is why Mosimane must review the physical training to see if he should reduce or increase it."
The former Red Devils defender went on to dismiss that their second-place finish in Group A behind Simba SC is an issue with Mamelodi Sundowns, Esperance or Wydad Casablanca awaiting in the quarter-final.
"Al Ahly finishing second doesn't bother me, because in any case, they will face strong teams," the 50-year-old explained.
"Al Ahly plays to win the tournament. Their goal is not just to reach the final, but to be crowned champions, and sooner or later they will face all the difficult teams.
"The most important thing is for the injured players to return, especially as they have a hectic schedule ahead of them."
The depleted Ahly squad take on Al Nasri in the round of 32 of the Egypt Cup this evening at Al-Salam Stadium in Cairo (21:30).