The record eight-time African Champions League winners will face off against the Absa Premiership champions in a repeat of last season's quarter-final.
With Sundowns having thrashed Ahly 5-1 on aggregate, the tie has been identified as a revenge encounter for the Club of the Century.
Two weeks ahead of their first-leg on Cairo on 29 February, the club has reached an agreement with the Ministry Youth and Sports.
Egyptian football fans have suffered a stadium ban for the past eight years since the Port Said riot and for spectators to attend needs confirmation from the government.
And now it's been confirmed that the game has been moved from their home ground to the national stadium with 50 percent capacity allowed.
"The Minister of Youth Sport, Ashraf Sobhy, told Al Ahly president Mahmoud El-Khatib that the game will be played at the Cairo International Stadium," Club CEO Mohamed Morgan told OnSport.
"The club president was in constant call with Ashraf Sobhy to move the encounter from the Al-Salam stadium to the Cairo International Stadium."
The return leg of the quarter-final tie is scheduled to take place at the Lucas Masterpieces Moripe Stadium on 7 March.