Three of their key players have been ruled out of the cup clash on November 23 after picking up cards in the 3-2 win over Orlando Pirates.
Amakhosi will host United at Mbombela Stadium without the services of goalkeeper Daniel Akpeyi, central midfielder Willard Katsande and centre-back Erick Mathoho.
Katsande and Akpeyi received their fourth bookings of the season while Mathoho received a red card during an exciting Soweto Derby at FNB Stadium.
The Soweto giants are now expected to recall Bruce Bvuma to replace Akpeyi in goal even though they have recently re-signed young Brylon Peterson.
Kearyn Baccus is also expected to make his return from injury to replace Katsande in the middle of the park for the trip to Nelspruit.