The Spanish defender has struggled with injury since joining the French club on a free transfer from Real Madrid in the off-season.
There was some good news this week as the 35-year-old joined his teammates for training, but he will not feature against Nantes on Saturday evening.
"A World Cup winner like Sergio Ramos, with his competitive level and mentality, is going to find it difficult to accept not playing as much as he would like, but he is very strong," Pochettino told the media, as per Goal.
"He is working extremely hard, and we think he is making good progress. We have to be patient, and he has been. That refers to his maturity, so we think he can be back in the squad soon.
"He has been in full training three times this week. He is coping well with the workload and this is an important step to getting closer to competing."