Paris Saint-Germain have lost back-to-back games in Ligue 1 following a 1-0 loss at home to Olympique Lyon on Sunday evening.
Lionel Messi made his 50th league appearance for the host, who brought Marquinhos, Achraf Hakimi and Renato Sanchez back in the starting line-up from the loss to Stade Rennes.
It was a decent opening for the league leaders that very nearly resulted in the deadlock when a dink from Vitinha following a clever pass flashed the woodwork.
Newly-installed French captain Kylian Mbappe went close again for the host from a move in-behind and an exchange of passes, but he dinked past Antony Lopes.
Lyon were forced to make a substitution during the midway period of the first half as an injury forced Amin Sarr off and had Bradley Barcola come to take his place.
Barcola got stuck in moments after entering when a loose ball slipped off his grasp and rolled to Alexandre Lacazette, who then drew a foul of Gianluigi Donnarumma to win a penalty.
The former Arsenal striker stepped to the fore following the spot-kick, but was unable to convert and left the reigning league champions off the hook.
Lyon maintained the momentum and hit the front ten minutes in the second half after Barcola popped up at the far post of the area and turned in Sael Kumbedi's assist.
Barcola continued to unsettle the host and looked to double his cushion with a speculative shot after working a cutback, but Donnarumma parried.
PSG struggled to carve openings and were caught chasing shadows much of the time thus evidently succumbed to another disappointing loss in the title race.
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